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KMID : 0894520190230010001
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Development & Reproduction
2019 Volume.23 No. 1 p.1 ~ p.9
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Role of Type 1 Inositol 1,4,5-triphosphate Receptors in Mammalian Oocytes
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Yoon Sook-Young
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Abstract
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The ability of oocytes to undergo normal fertilization and embryo development is acquired during oocyte mat?uration which is transition from the germinal vesicle stage (GV), germinal vesicle breakdown (GVBD) to metaphase of meio?sis II (MII). Part of this process includes redistribution of inositol 1, 4, 5-triphosphate receptor (IP3R), a predominant Ca2+ channel on the endoplasmic reticulum membrane. Type 1 IP3R (IP3R1) is expressed in mouse oocytes dominantly. At GV stage, IP3R1 are arranged as a network throughout the cytoplasm with minute accumulation around the nucleus. At MII stage, IP3R1 diffuses to the entire cytoplasm in a more reticular manner, and obvious clusters of IP3R1 are observed at the cortex of the egg. This structural reorganization provides acquisition of [Ca2+]i oscillatory activity during fertilization. In this review, general properties of IP3R1 in somatic cells and mammalian oocyte are introduced.
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KEYWORD
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IP3R1, Oocytes, Fertilization, PLCzeta
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